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Lisandro Martínez was crying when they took him out of the field on a stretcher in Old Trafford during the Manchester United match against Crystal Palace.
The Argentine was replaced in 83 minutes by the Dutch defender Matthijs of Ligt with the hosts following Oliver Glasner 2-0.
The Frenchman Jean-Phillipe Mateta scored his second goal of the game shortly after the game resumed after Martínez's injury.
Nine minutes of detention time were indicated in Old Trafford after the unemployment at play.
United 2-0 defeat in Theater of Dreams means that, since the beginning of last season, only the wolves have lost more home games in the league than the Red Devils.
He also marks his fifth defeat at six in the league, and means that the palace has passed over them at the table, with United falling to the 13th.
Lisandro Martínez was crying after falling with what seemed to be a serious injury
Nine minutes of detention time were indicated at Old Trafford after the stop at play
The news will be a concern for Ruben Amorim, whose side fell 2-0 shortly after Martínez left the field
Palace has now won six of the last 12 Premier League meetings between the two clubs, even in four of its last six visits to Old Trafford, and collected 16 points from home since the beginning of December, more than any other superior club auxiliary.
When commenting on the Old Trafford incident, as he developed, Chris Wheeler of Mail Sport said: 'Only a few minutes after going to the goal (first) of Mateta, Martínez looks under a challenge of Sar march.
“It is the same area of the field when it suffered a serious knee injury against West Ham last season, and there will be fears that it has suffered a similar injury.”
That injury came in a draw in the FA Cup in the West Ham United last season, in the same area of the field, although this time it was not clear if the problem was an ankle or knee.
While the scope of the injury is still clear, losing Martínez for a prolonged period, as it seems to be the case, would be a great blow to Ruben Amorim.
The defender has started each game bar three of the 20 games of the Portuguese chief in charge so far.
With United Shelled for the injury, Mateta completed the misery of the local team with her second goal in the 89th minute before another nine minutes of time added by referee John Brooks.
The substitute Adam Wharton broke from the center of the field and fed Sarr, who chose Muñoz running from Yoro. He had the simple task of killing Mateta to score from short distance.
Speaking in Sky Sports after the game when asked about his orthopedic device, Palace Mateta striker said: 'I feel fantastic! We won these three points, we work hard and I am very happy.
'We know how they play with the new manager, we work in a plan during the week and we stick to the plan.
'We listen to the gaffer and work hard and I think we deserve this victory. I simply went down my head and worked hard and I think sometimes when you do that, you get the reward.